Tg(APOE_i2*R158C)1Lmh
Transgene Detail

Summary

• Symbol: Tg(APOE_i2*R158C)1Lmh
• Name: transgene insertion 1, Louis M Havekes
• MGI ID: MGI:3768070
• Synonyms: ApoE2(Arg158-Cys), Tg(APOE*2)1Lmh
• Transgene: Tg(APOE_i2*R158C)1Lmh Location: unknown
• Alliance: Tg(APOE_i2*R158C)1Lmh page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/J)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(APOE_i2*R158C)1Lmh expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APOE (348)

  Apoe	(MGI:88057)

• Mutation details: A construct carrying an 11-kB genomic fragment containing the human APOE*2 gene and endogenous promoter, and the intergenic region between APOCl and the APOCl pseudogene, harboring the postulated liver regulatory element (HCR, hepatic control region), was used to create transgenic mice. The human APOE*2 mutation is characterized by a Arg158Cys amino acid substitution. Northern blotting analysis indicates that this transgene is expressed in the liver. (J:37473)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:37473 van Vlijmen BJ, et al., In the absence of endogenous mouse apolipoprotein E, apolipoprotein E*2(Arg-158 --> Cys) transgenic mice develop more severe hyperlipoproteinemia than apolipoprotein E*3-Leiden transgenic mice. J Biol Chem. 1996 Nov 29;271(48):30595-602
• All: 5 reference(s)