Tg(Camk2a-RAP2A*G12V)1Shng
Transgene Detail

Summary

• Symbol: Tg(Camk2a-RAP2A*G12V)1Shng
• Name: transgene insertion 1, Morgan Sheng
• MGI ID: MGI:3762758
• Synonyms: Rap2V12
• Transgene: Tg(Camk2a-RAP2A*G12V)1Shng Location: unknown
• Alliance: Tg(Camk2a-RAP2A*G12V)1Shng page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Constitutively active, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Camk2a-RAP2A*G12V)1Shng expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  RAP2A (5911)

  Rap2a

  (MGI:97855)

  Expresses a G12V mutation

• Tg(Camk2a-RAP2A*G12V)1Shng expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Camk2a (MGI:88256)

• Mutation details: The vector contains the mouse Camk2a promoter directing expression of the human RAP2A (G12V (V12) mutant). Immunohistochemistry and immunoblotting show expression in mouse forebrain (including the hippocampus, cortex, thalamus, striatum, and amygdala). (J:138992)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:138992 Ryu J, et al., Constitutively active Rap2 transgenic mice display fewer dendritic spines, reduced extracellular signal-regulated kinase signaling, enhanced long-term depression, and impaired spatial learning and fear extinction. J Neurosci. 2008 Aug 13;28(33):8178-88
• All: 1 reference(s)