Tg(Alb-F5)2Dgi
Transgene Detail

Summary

• Symbol: Tg(Alb-F5)2Dgi
• Name: transgene insertion 2, David Ginsburg
• MGI ID: MGI:3709371
• Synonyms: AlbfvC
• Transgene: Tg(Alb-F5)2Dgi Location: unknown
• Alliance: Tg(Alb-F5)2Dgi page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1 or C57BL/6 x (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Alb-F5)2Dgi expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	F5 (MGI:88382)

• Mutation details: The transgenic construct has the mouse albumin promoter driving expression of the murine F5 (FV) gene including the entire coding sequence. An IRES-EGFP cassette with a bacterial gene wasinserting after the F5 coding sequence. A chimeric intron with optimized splice signals was introduced upstream of the F5 cDNA enhance gene expression. Transgenic F5 expression is restricted to the liver. EGFP expression is not detected. (J:86150)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:86150 Sun H, et al., The murine platelet and plasma factor V pools are biosynthetically distinct and sufficient for minimal hemostasis. Blood. 2003 Oct 15;102(8):2856-61
• All: 3 reference(s)