Tg(Syn1-ADCY7)11004Btab
Transgene Detail

Summary

• Symbol: Tg(Syn1-ADCY7)11004Btab
• Name: transgene insertion 11004, Boris Tabakoff
• MGI ID: MGI:3695128
• Synonyms: Adcy7^huTG
• Transgene: Tg(Syn1-ADCY7)11004Btab Location: unknown
• Alliance: Tg(Syn1-ADCY7)11004Btab page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Syn1-ADCY7)11004Btab expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ADCY7 (113)

  Adcy7

  (MGI:102891)

• Mutation details: This transgene consists of a 4.5 kb fragment of the rat synapsin I promotor, a 3.6 kb fragment of human ADCY7 cDNA, and a 650 bp fragment of the human growth hormone gene. Expression is confined to the central nervous system. Three lines (11004, 11012, and 10115) with high levels of expression were created which all have identical phenotype. One of these lines (10115) was generated using FVB/N oocytes while the other 2 used hybrid C57BL/6 x SJL oocytes. This is a representative record for all three lines (J:116797)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:116797 Yoshimura M, et al., Overexpression of type 7 adenylyl cyclase in the mouse brain enhances acute and chronic actions of morphine. Mol Pharmacol. 2000 Nov;58(5):1011-6
• All: 2 reference(s)