hpmd Gene Detail

Summary

• Symbol
  hpmd
• Name
  hypoplastic mandible
• Synonyms
  line 171a

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:3576012
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome Unknown

Human Diseases

• Diseases
  1 with hpmd mouse models

Human Disease

Mouse Models

Weissenbacher-Zweymuller syndrome

IDs

Weissenbacher-Zweymuller syndrome      

DOID:4258
ICD10CM:Q87.0
MESH:D010855
NCI:C85010
OMIM:261800
UMLS_CUI:C0031900

View 1 model

Mouse Models

Human Disease Modeled: Weissenbacher-Zweymuller syndrome

Allelic Composition	Genetic Background	Reference	Phenotypes
hpmd/hpmd	Not Specified	J:75360	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  5 phenotypes from 1 allele in 1 genetic background
  2 phenotype references
  

• All Mutations and Alleles
  1
• Chemically induced (ENU)
  1
• Find Mice (IMSR)
  0 strains or lines available

Mutant mice exhibit hypoplastic mandible, defects in the xyphoid process and abnormalities in the derivatives of the first branchial arch.

References

• Summaries
  All 2

  Diseases 1

  Phenotypes 2
• Earliest
  J:75360 Herron BJ, et al., Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis. Nat Genet. 2002 Feb;30(2):185-9
• Latest
  J:285676 Suzuki A, et al., Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis. Mech Dev. 2018 Apr;150:21-27