Tg(TcraDN32D3)78Alhn
Transgene Detail

Summary

• Symbol: Tg(TcraDN32D3)78Alhn
• Name: transgene insertion 78, Agnes Lehuen
• MGI ID: MGI:3526073
• Synonyms: Tcra-Va14-Ja281, Tg A14-78, Tg(TcraCD1d1)78Alhn, Valpha14-Jalpha281 Tg, Valpha14Jalpha281 Tg
• Transgene: Tg(TcraDN32D3)78Alhn Location: unknown
• Alliance: Tg(TcraDN32D3)78Alhn page

Transgene origin

• Strain of Origin: NOD

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(TcraDN32D3)78Alhn expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)

• Mutation details: The transgene contains the V-J exon from the rearranged Tcra gene of the C57BL/6-derived, CD1d1-reactive T cell hybridoma DN32D3; this cell line has the Tcra-V14-J281 rearrangement invariably borne by NK1 T lymphocytes. (J:93798)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

The founder line for this transgene, designated by its creators Tg A14-78, was one of six generated in NOD; the other lines were designated Tg A14-10, -14, -36, -86 and -95.

References

• Original: J:93558 Lehuen A, et al., Overexpression of natural killer T cells protects Valpha14- Jalpha281 transgenic nonobese diabetic mice against diabetes. J Exp Med. 1998 Nov 16;188(10):1831-9
• All: 3 reference(s)