Tg(CD2-Il2rg)M1-2Ttg
Transgene Detail

Summary

• Symbol: Tg(CD2-Il2rg)M1-2Ttg
• Name: transgene insertion M1-2, Tadatsugu Taniguchi
• MGI ID: MGI:3054424
• Synonyms: IL-2R gamma c M1-2 tg, Tg(CD2-Il2rg-deltaPro291-Ala369)2Ttg, Tg(Il2rg)M1-2
• Transgene: Tg(CD2-Il2rg)M1-2Ttg Location: unknown
• Alliance: Tg(CD2-Il2rg)M1-2Ttg page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CD2-Il2rg)M1-2Ttg expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Il2rg (MGI:96551)

• Mutation details: A cDNA encoding mouse interleukin 2 receptor gamma chain lacking the carboxyl-terminal 79 amino acids of the 85-amino acid cytoplasmic domain was inserted into an expression vector containing 5 kb of 5' flanking sequence, including the promoter, transcription initiation site and first intron, and 5.5 kb of 3' flanking sequence including the locus control region (LCR) of the human CD2 gene. The transgene product was found to be expressed on CD4+ CD8+ thymocytes and on splenic and peripheral blood T lymphocytes. (J:92738)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:92738 Tsujino S, et al., Differential requirement of the cytoplasmic subregions of gamma c chain in T cell development and function. Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10514-9
• All: 1 reference(s)