Tg(tetO-Jun)5Nes
Transgene Detail

Summary

• Symbol: Tg(tetO-Jun)5Nes
• Name: transgene insertion 5, Eric Nestler
• MGI ID: MGI:3053118
• Synonyms: E line, TetOp-FLAG-deltac-Jun, TetOp-FLAG-deltacJun line E
• Transgene: Tg(tetO-Jun)5Nes Location: unknown
• Alliance: Tg(tetO-Jun)5Nes page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Dominant negative, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: A truncated dominant negative form of the Jun transcription factor is expressed by this transgene. Transcription is directed by a tetracycline-responsive promoter element (TRE). When bred with another transgenic mouse expressing tetracycline-controlled transactivator protein (tTA) to create a bitransgenic animal, Fosb expression can be negatively regulated with the tetracycline analog, doxycycline. (J:83308)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:83308 Peakman MC, et al., Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine. Brain Res. 2003 Apr 25;970(1-2):73-86
• All: 5 reference(s)