Tg(KRT14-HPV16)wt1Dh
Transgene Detail

Summary

• Symbol: Tg(KRT14-HPV16)wt1Dh
• Name: transgene insertion wt1, Douglas Hanahan
• MGI ID: MGI:3047406
• Synonyms: HPV16, HPV16/E2, K14-1203#1, K14-HPV16
• Transgene: Tg(KRT14-HPV16)wt1Dh Location: unknown
• Alliance: Tg(KRT14-HPV16)wt1Dh page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene comprises the entire early coding sequence from wild-type human papillomavirus 16 (HPV16), extending from nucleotide (nt) 97 through nt 6152, flanked upstream by approximately 2 kilobases of DNA including the promoter/enhancer of the human keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner) gene and downstream by 500 base pairs derived from the 3' untranslated sequence of the same gene, including its polyadenylation signal. The keratin 14 promoter drives expression of the transgene in basal cells of the squamous epithelium. (J:20125)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(KRT14-HPV16)wt1Dh

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:20125 Arbeit JM, et al., Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice. J Virol. 1994 Jul;68(7):4358-68
• All: 50 reference(s)