Tg(ACTB-gag/THRA1)AVen
Transgene Detail

Summary

• Symbol: Tg(ACTB-gag/THRA1)AVen
• Name: transgene insertion A, Bjorn Vennstrom
• MGI ID: MGI:3044356
• Synonyms: BVe-1, gag-v-erbA, hAP/v-erbA, v-erbA
• Transgene: Tg(ACTB-gag/THRA1)AVen Location: unknown
• Alliance: Tg(ACTB-gag/THRA1)AVen page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/J)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(ACTB-gag/THRA1)AVen expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  chicken	THRA (396251)

• Mutation details: The transgene consists of 3 kb of 5' flanking sequence, exon 1 (comprising additional 5' untranslated sequence), and the first intron, including the 3' splice site, from the human beta-actin gene; the v-erbA oncogene, which comprises the avian erythroblastosis retroviral gag gene followed by a mutated chicken thryroid receptor hormone alpha gene; and the SV40 polyadenylation signal. (J:90554)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:90554 Barlow C, et al., Thyroid abnormalities and hepatocellular carcinoma in mice transgenic for v-erbA. EMBO J. 1994 Sep 15;13(18):4241-50
• All: 1 reference(s)