Tg(Prnp-ATXN7*92Q)6076Als
Transgene Detail

Summary

• Symbol: Tg(Prnp-ATXN7*92Q)6076Als
• Name: transgene insertion 6076, Albert R La Spada
• MGI ID: MGI:2183508
• Synonyms: ATXN-92Q, PrP-SCA7-c92Q, Tg(SCA7)c92QAls
• Transgene: Tg(Prnp-ATXN7*92Q)6076Als Location: unknown
• Alliance: Tg(Prnp-ATXN7*92Q)6076Als page

Transgene origin

• Strain of Origin: (C57BL/6J x C3H/HeJ)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-ATXN7*92Q)6076Als expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ATXN7 (6314)

  Atxn7

  (MGI:2179277)

• Mutation details: The coding region of human SCA7, containing 92 CAG repeats, was inserted into a murine prion protein promoter (MoPrP) construct. Expression was targeted to the outer nuclear layer, the inner nuclear layer, and the ganglion cell layer of the retina. Two lines (6076-92Q and 6561-92Q) were made. (J:71971)
• Inheritance: Not Specified

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:71971 La Spada AR, et al., Polyglutamine-expanded ataxin-7 antagonizes crx function and induces cone-rod dystrophy in a mouse model of sca7. (Erratum: Neuron 2001;32:957). Neuron. 2001 Sep 27;31(6):913-27
• All: 5 reference(s)