Tg(Pbsn-cre)4Prb
Transgene Detail
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Symbol: |
Tg(Pbsn-cre)4Prb |
Name: |
transgene insertion 4, Pradip Roy-Burman |
MGI ID: |
MGI:2385927 |
Synonyms: |
ARR2PB-Cre, PB-Cre, PbCre4, PB-Cre4 |
Transgene: |
Tg(Pbsn-cre)4Prb Location: unknown
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Alliance: |
Tg(Pbsn-cre)4Prb page
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Prostate hyperplasia and low-grade prostate intraepithelial neoplasia in Brca2tm1Brn/Brca2tm1Brn Tg(Pbsn-cre)4Prb/0 mice
Show the 9 phenotype image(s) involving this allele.
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Transgene Type: |
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Transgenic (Recombinase) |
Mutation: |
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Insertion
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Tg(Pbsn-cre)4Prb expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Homolog in Mouse |
Note |
rat |
Pbsn (54193) |
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Mutation details: The transgene is composed of the cre recombinase gene under the control of a composite promoter derived from rat Pbsn. The rat Pbsn promoter drives postnatal transgene expression in the prostatic epithelium. The transgene is expressed postnatally in prostatic epithelium with the highest level of expression in the lateral lobe of the prostate gland. A very low level of transgene expression was detected in the seminal vesicles, testes, and ovaries. No transgene expression was detected in any of the other tissue types examined.
(J:68167)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Pbsn
(rat)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 2 strains available
Cell Lines: 0 lines available
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Original: |
J:68167 Wu X, et al., Generation of a prostate epithelial cell-specific Cre transgenic mouse model for tissue-specific gene ablation. Mech Dev. 2001 Mar;101(1-2):61-9 |
All: |
276 reference(s) |
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