Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  6
• Reference
  J:17778 Ryan J, et al., KRAS2 as a genetic marker for lung tumor susceptibility in inbred mice. J Natl Cancer Inst. 1987 Dec;79(6):1351-7
• ID
  MGI:5705640

Genes

Gene
Pas1
Kras

Notes

• Experiment
  Analysis of a series of recombinant inbred strains (AXB, BXA) that developed from reciprocal crosses between a highly susceptible strain A/J and a highly resistant strain C57BL/6J, revealed a statistically significant three fold difference in lung tumor susceptibility on the basis of the Kras genotype.
  
  Further analysis of individual mice from an (C57BL/6J x A/J)F2 cross also demonstrated a three fold difference in tumor susceptibility on the basis of Kras alleleic variation.
  F2 data suggest that the A/J allele of Kras is dominant over the allele for C57BL/6J.
  However, data also show that there is not a direct correspondence between Kras genotype and lung tumor susceptibility. In an indiviual animal or single inbred strain the Kras genotype alone is not predictive. This finding is probably a reflection of the polygenic nature of of the inheritance of lung tumor susceptibility.
  
  A three-locus genetic model derived from analysis of the AXB and BXA RI strains proposes one dominant locus (Pas1) and two minor loci Pas2 and Pas3 determining lung tumor susceptibility. See J:8075.