Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  18
• Reference
  J:182797 Wang SS, et al., Disruption of the aortic elastic lamina and medial calcification share genetic determinants in mice. Circ Cardiovasc Genet. 2009 Dec;2(6):573-82
• ID
  MGI:5697470

Genes

Gene	Assay Type
Aasm3	visible phenotype

Notes

• Experiment
  Linkage analysis was performed on 332 (B6.129P2-Apoe-tm1Unc/J x C3.129P2(B6)-Apoe-tm1Unc)F2 intercross mice using 1347 markers to identify QTL associated with aortic medial disruption. Parental strain C3H/HeJ displays higher susceptibility to aortic medial disruption than C57BL/6J.
  
  QTL Aasm3 maps to 28.5 - 77.9 Mb on Chromosome 18 with a peak LOD score of 4.17 (sex-covariate) or 4.74 (sex-interaction) at 43.7 cM in linkage with aortic medial disruption. Aasm3 is a male-specific QTL.
  
  C57BL/6J alleles confer increased susceptibility to aortic medial disruption at the Aasm3 locus.