Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  2
• Reference
  J:187953 Zhang Z, et al., Genetic analysis of atherosclerosis and glucose homeostasis in an intercross between C57BL/6 and BALB/cJ apolipoprotein E-deficient mice. Circ Cardiovasc Genet. 2012 Apr 1;5(2):190-201
• ID
  MGI:5661851

Genes

Gene	Assay Type
Ath41	visible phenotype
D2Mit328

Notes

• Experiment
  Linkage analysis was performed on 266 female (B6.129P2-Apoe^tm1Unc/J x C.129P2(B6)-Apoe^tm1Unc)F2 intercross mice using 130 SNP markers to identify QTL associated with atherosclerotic susceptibility (atherosclerotic lesion size at aortic root). Parental strain B6.129P2-Apoe^tm1Unc/J exhibits higher incidence of atherosclerosis when compared to C.129P2(B6)-Apoe^tm1Unc.
  
  QTL Ath41 maps to 26.2 - 64.2 cM on Chromosome 2 with a peak LOD score of 3.77 at D2Mit328 (52.2 cM) in linkage with atheroscleroticlesion size. B6.129P2-Apoe^tm1Unc/J alleles confer increased susceptibility to atherosclerotic lesion size with an additive mode of inheritance.