Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  7
• Reference
  J:23719 Drake CG, et al., Analysis of the New Zealand Black contribution to lupus-like renal disease. Multiple genes that operate in a threshold manner. J Immunol. 1995 Mar 1;154(5):2441-7
• ID
  MGI:5644330

Genes

Gene	Assay Type
Nba3	PCR amplified length variant
D7Mit17	PCR amplified length variant

Notes

• Experiment
  NZB and NZW mice spontaneously develop an autoimmune process remarkably simiar to human systemic lupus erythematosus. To identify additional NZB contributors to lupus like disease 90 female (NZB x SM/J)F1 x NZW backcross mice were followed for the development of sever renal disease and were comprehensively phenotyped. To identify disease associated loci the same mice were genotyped using PCR.
  
  A statistically significant association with disease was noted at 6 separate locations on Chrs 1, 4, 7, 10, 13 and 19. p<0.05 was the cutoff to define statistical significance. Mice carrying the NZB allele at five of these 6 positions died from severe renal disease.
  
  Of the six significant loci evident in the backcross, the level of association with disease at the Chromosome 1 locus was particularly strong, p<0.02, peaking with marker D1Mit111 at 61cM. This QTL has been named Nba2.
  
  The Chromosome 7 locus has been labeled Nba3, peaking with marker D7Mit17, p<0.008 at 45.0cM