Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:66474 Clapcott SJ, et al., Evidence for genomic imprinting of the major QTL controlling susceptibility to trypanosomiasis in mice. Parasite Immunol. 2000 May;22(5):259-63
• ID
  MGI:5637681

Genes

Gene	Assay Type
Tir3	reported elsewhere
D1Mit102

Notes

• Experiment
  Four backcross populations [(C57BL/6JOlaHsd x BALB/cOlaHsd)F1 x BALB/cOlaHsd, BALB/cOlaHsd x (C57BL/6JOlaHsd x BALB/cOlaHsd)F1, (BALB/cOlaHsd x C57BL/6JolaHsd)F1 x BALB/cOlaHsd, and BALB/cOlaHsd x (C57BL/6JOlaHsd x BALB/cOlaHsd)F1] were used to assess the effect of imprinting at loci involved in trypanosomiasis survival (Tir1, Tir2, and Tir3).
  
  Tir1 showed significant linkage for trypanosomiasis survival time with parent of origin at D17Mit16 (LOD = 5.9). Animals from BALB/cOlaHsd fathers and (C57BL/6JOlaHsd x BALB/cOlaHsd)F1 or (C57BL/6JOlaHsd x BALB/cOlaHsd)F1 mothers exhibited higher survival rates than animals from (C57BL/6JOlaHsd x BALB/cOlaHsd)F1 or (C57BL/6JOlaHsd x BALB/cOlaHsd)F1 fathers and BALB/cOlaHsd mothers. Authors speculate that genomic imprinting may play a role in trypanosomiasis survival at Tir1.
  
  Tir3 showed suggestive linkage for trypanosomiasis survival time and parent of origin at D1Mit102 (LOD = 2.2-2.8), and Tir2 was not detected for linkage to survival time and parent of origin.