Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  11
• Reference
  J:170533 Lawson HA, et al., The importance of context to the genetic architecture of diabetes-related traits is revealed in a genome-wide scan of a LG/J x SM/J murine model. Mamm Genome. 2011 Apr;22(3-4):197-208
• ID
  MGI:4948139

Genes

Gene
Ddiab31
Ddiab32
Ddiab33
Ddiab34
Ddiab35

Notes

• Experiment
  The mice used in this study were from the F16 generation of
  the LG/J X SM/J Advanced Intercross Line (Wustl:LG,SM-G16).
  
  The authors indicated 70 trait-specific QTL mapping to 64 locations,
  and of these 70 a total of 17 are significant at the genome-wide level. Fifty three are significant at the chromosome level.
  
  The 17 genome wide significant QTL are indicated with an '*' and can be viewed here on their respective chromosome mapping records (NCBI37/mm9).
  
  The authors mentioned that phenotypic variation in response to glucosestresswas indicated by using an intraperitoneal injection of 0.01 ml of 10% glucose solution per
  gram of body weight. The measurements taken over the course of 2 hours were used to calculate the area under the curve (AUC), which was used as overall measure of glucose tolerance.
  
  Phenotypes were as follows:
  AUC_10wks indicates under the curve at 10 weeks
  AUC_20wks indicates area under the curve at 20 weeks
  bGLC_10wks indicates basal glucose level at 10 weeks
  bGLC_20wks indicates basal glucose level at 20 weeks,
  GLC indicates serum glucose level at necropsy
  INS indicates serum insulin level at necropsy
  
  
  Chr MGI Author Pheno LOD Peak Mb 5 prime 3 Prime
  
  11 *Ddiab31 Ddiab11a INS 4.98 7.32 6.46 7.85
  11 *Ddiab32 Ddiab11b INS 8.15 12.52 11.51 13.77
  11 Ddiab33 Ddiab11c AUC_20wks 2.88 80.69 80.01 81.6
  11 Ddiab34 Ddiab11d AUC_20wks 3.15 105.13 104.43 106.39
  11 Ddiab35 Ddiab11e AUC_20wks 3.03 108.38 107.61 109.26
  
  Table 1 notes the presence of glucose and/or insulin affecting genes within the mapped QTL interval as markers Igfbp1 and Igfbp3 for QTL Ddiab31; and marker Grb10 within the interval of QTL Ddiab32.