Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  8
• Reference
  J:170533 Lawson HA, et al., The importance of context to the genetic architecture of diabetes-related traits is revealed in a genome-wide scan of a LG/J x SM/J murine model. Mamm Genome. 2011 Apr;22(3-4):197-208
• ID
  MGI:4948136

Genes

Gene
Ddiab25
Ddiab26

Notes

• Experiment
  The mice used in this study were from the F16 generation of
  the LG/J X SM/J Advanced Intercross Line (Wustl:LG,SM-G16).
  
  The authors indicated 70 trait-specific QTL mapping to 64 locations,
  and of these 70 a total of 17 are significant at the genome-wide level. Fifty three are significant at the chromosome level.
  
  The 17 genome wide significant QTL are indicated with an '*' and can be viewed here on their respective chromosome mapping records (NCBI37/mm9).
  
  The authors mentioned that phenotypic variation in response to glucosestresswas indicated by using an intraperitoneal injection of 0.01 ml of 10% glucose solution per
  gram of body weight. The measurements taken over the course of 2 hours were used to calculate the area under the curve (AUC), which was used as overall measure of glucose tolerance.
  
  Phenotypes were as follows:
  AUC_10wks indicates under the curve at 10 weeks
  AUC_20wks indicates area under the curve at 20 weeks
  bGLC_10wks indicates basal glucose level at 10 weeks
  bGLC_20wks indicates basal glucose level at 20 weeks,
  GLC indicates serum glucose level at necropsy
  INS indicates serum insulin level at necropsy
  
  
  Chr MGI Author Pheno LOD Peak Mb 5 prime 3 Prime
  
  8 *Ddiab25 Ddiab8a AUC_10wks 4.26 29.36 21.55 39.08
  8 *Ddiab26 Ddiab8b AUC_10wks 4.11 71.23 64.98 75.5
  
  Table 1 notes the presence of glucose and/or insulin affecting genes within the mapped QTL interval as markers Ikbkb and Adrb3 for QTL Ddiab25; and markers Cpe, Lpl, Npy1r, Pik3r2, Rab3a and Slc27a1 within the interval of Ddiab26.