Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  6
• Reference
  J:37547 Street VA, et al., The type 1 inositol 1,4,5-trisphosphate receptor gene is altered in the opisthotonos mouse. J Neurosci. 1997 Jan 15;17(2):635-45
• ID
  MGI:48061

Genes

Gene	Allele	Assay Type	Description
Mitf	Mitf^Mi-wh	visible phenotype
Itpr1		Southern analysis	Itpr1 cDNA1

Notes

• Reference
  The authors provide data showing that the Opt phenotype is the result of a deletion in Itpr1.
• Experiment
  The opt mutation is maintained in a repulsion intercross with Mitf^Mi-wh. Heterozygous opt mice can be identified by coat color. Southern hybridization using an Itpr1 molecular probe was informative in showing that opt heterozygotes were also heterozygous at the Itpr1 locus. The hybridization results suggest that Iptr1 and opt cosegregate and are thus closely linked on mouse Chromosome 6.