Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  18
• Reference
  J:34941 Pataer A, et al., Two dominant host resistance genes to pre-B lymphoma in wild-derived inbred mouse strain MSM/Ms. Cancer Res. 1996 Aug 15;56(16):3716-20
• ID
  MGI:47405

Genes

Gene	Assay Type
D18Mit90	PCR amplified length variant
Msmr2	resistance/susceptibility
D18Mit140	PCR amplified length variant

Notes

• Experiment
  All the chromosomes of progeny from a (MSM/Ms x SL/Kh)F1 x SL/Kh backcross were scanned for linkage of lymphoma susceptibility with 79 polymorphic microsatellite loci spaced 15 cM - 30 cM apart. Authors found a significant linkage disequilibrium in the proximal segment of mouse Chromosome 18, between D18Mit90 (28 cM) and D18Mit140 (37 cM) These data map Msmr2 between D18Mit90 and D18Mit140 on mouse Chromosome 18. The MSM/Ms-derived allele at Msmr2 is associated with dominant lymphoma resistance whereas the SL/Kh-derived allele is associated with susceptibility.