Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  6
• Reference
  J:3876 Gariboldi M, et al., A major susceptibility locus to murine lung carcinogenesis maps on chromosome 6. Nat Genet. 1993 Feb;3(2):132-6
• ID
  MGI:47208

Genes

Gene	Assay Type	Description
Met	reported elsewhere
Mtv23	Southern analysis	Mtv23 probe
Cd8b1	reported elsewhere
D6Mit10	PCR amplified length variant	M78
Raf1	reported elsewhere
D6Mit13	PCR amplified length variant	D34
Pas14	resistance/susceptibility
D6Mit14	PCR amplified length variant	M190
Kras	reported elsewhere
D6Int1	PCR amplified length variant	D6Int1-pA, D6Int1-pB

Notes

• Experiment
  Eighty seven progeny from a (A/J x C3H/He)F2 intercross were analyzed to map the following loci to mouse Chromosome 6: Met - Mtv23 - Cd8b1 - D6Mit10 - Raf1 - D6Mit13a - D6Mit14 - Pas1 - Kras - D6Int1. Only male progeny used. Authors map the QTL for a majorlung tumor susceptibilty gene (Pas1) between D6Mit10 and D6Int1 on mouse Chromosome 6 using linkage analysis of lung tumor susceptibilty in a (A/J x C3H/He)F2 intercross. Significant p values (0.0001) were obtained between Pas1 and D6Mit13, D6Mit14, Kras and D6Int1. Authors state Mtv23 had been previously reported to be near Cd8b1, however this study places it 1 cM distal to Met.
  
  1.28.2016 Curator Note: Because Pas1 was mapped using AXB, BXA and (C57BL/6J x A/J)F2 mice, which differ from the mapping population used here, we condiser the current study a separate mapping experiment and have named this Pas14.