Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:31797 Santos J, et al., Allelic losses on chromosome 4 suggest the existence of a candidate tumor suppressor gene region of about 0.6 cM in gamma-radiation-induced mouse primary thymic lymphomas. Oncogene. 1996 Feb 1;12(3):669-76
• ID
  MGI:46453

Genes

Gene	Assay Type	Description
D4Mit50	PCR amplified length variant	B660
D4Mit17	PCR amplified length variant	D1
D4Wsm1	PCR amplified length variant	F1
Tlsr1	resistance/susceptibility
D4Mit9	PCR amplified length variant	M241
D4Mit205	PCR amplified length variant	M205
D4Mit12	PCR amplified length variant	M15
Tlsr2	resistance/susceptibility
D4Mit54	PCR amplified length variant	B463
D4Mit13	PCR amplified length variant	M169

Notes

• Experiment
  PCR analysis using microsatellite DNA polymorphic markers was preformed in (C57BL/6J x RF/J)F1 animals. Allelic losses were detected in 21/47 gamma-radiation induced thymic lymphomas. Analysis of markers located on six other chromosomes as well as on the proximal region of mouse Chromosome 4 indicated the existance of a tumor suppressor gene region (Tlsr1) on mouse Chromosome 4 of about 0.6 cM between the makers D4Wsm1 and D4Mit9. Additionally, a more distal tumor suppressor gene region (Tlsr2) was found centered at D4Mit54. From these data the following order of loci was determined on mouse Chromosome 4: D4Mit50, D4Mit17, D4Wsm1, Tlsr1, D4Mit9, D4Mit205, D4Mit12, Tlsr2, D4Mit54, D4Mit13.