Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  2
• Reference
  J:29231 De Sanctis GT, et al., Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice. Nat Genet. 1995 Oct;11(2):150-4
• ID
  MGI:45761

Genes

Gene	Assay Type	Description
D2Mit397	PCR amplified length variant	MJ4670
Bhr1	visible phenotype
D2Mit266	PCR amplified length variant	MT2735

Notes

• Experiment
  Airway hyperresponsiveness in mice is inherited as a polygenic trait in C57BL/6J and A/J mice. The asthma-like phenotype in A/J mice is expressed differently then the phenotype expressed in C57BL/6J mice, therefore allowing for the quantitative mapping (QTL) of this trait in (C57BL/6J x A/J)F1 x C57BL/6J backcross mice. A genome wide scan using Mit markers indicated that one such locus, Bhr1, mapped to mouse Chromosome 2 between D2Mit397 and D2Mit266 with a LOD score of 3.0.
  
  Bhr3 interacts with Bhr1 andBhr2. Homozygosity for C57BL/6J-derived alleles at either Bhr1 or Bhr3 confers simlilar decrease in airway hyperresponsiveness as homozygosity at both Bhr1 and Bhr3.
  
  Heterozygosity at either Bhr2 or Bhr3 confers similar increase in airway hyperresponsiveness as heterozygosity at both Bhr2 and Bhr3.