Mapping Data

Experiment

• Experiment
  HYBRID
• Chromosome
  16
• Reference
  J:4467 Reeves RH, et al., Genetic linkage in the mouse of genes involved in Down syndrome and Alzheimer's disease in man. Brain Res. 1987 Sep;388(3):215-21
• ID
  MGI:45544

Genes

Gene
App

Notes

• Reference
  Revised gene symbol: App (formerly Cvap).
• Experiment
  Somatic cell hybrids were from fusions of T(2;16)28H mouse cells homozygous for translocated Chromosomes 2¹⁶ and 16² and Chinese hamster cell line Ade-C neo^r. Hybrids selected in purine free medium will require the distal portion of mouse Chromosome 16 (2¹⁶) because 2¹⁶ contains the mouse Prgs locus that can compensate for the purine deficient hamster Ade-C cells. Five independent Prgs+ neo^r clones were analyzed. All 5 contained mouse App, mapping this locus to the C3-ter region of mouse Chromosome 16, distal to the T28H breakpoint.

HYBRID

• Band
  C3-qter