Mapping Data

Experiment

• Experiment
  TEXT-Physical Mapping
• Chromosome
  11
• Reference
  J:22797 Kurtz A, et al., The mouse homolog of the human Miller-Dieker chromosomal region (MDCR) maps to mouse chromosome 11 in close proximity to Mov9 and D11Nds1. Mamm Genome. 1995 Feb;6(2):145-6
• ID
  MGI:44745

Genes

Gene	Assay Type	Description
Trp53	overlapping clones	D2S2RAC2
D11Mit7	overlapping clones	B2S2RGC4, B17S4RFC5, D41D9
Mov9	overlapping clones	B2S2RGC4, B17S4RFC5, B2S2RBC2, B21S2RGC1, C11405, D41D9
D11Nds1	overlapping clones	B2S2RGC4, B17S4RFC5, B2S2RBC2, B21S2RGC1, C11405, D41D9
Pafah1b1	Southern analysis	Mdsh genomic1, B2S2RGC4, B2S2RBC2, C114D5
Evi2a	overlapping clones	C31G5

Notes

• Experiment
  Physical mapping of selected YACs indicated a location for Mdsh to a region on Chromosome 11 bounded by Evi2 and Trp53. Both Evi2 and Trp53 were on YAC clones outside of a 650kb YAC that carried D11Nds1, Mov9 and D11Mit7. Based on the analysis of various YACs, the maximum distance between D11Nds1, Mov9 and D11Mit7 is less than 260kb. Using Southern blotting, the Mdsh probe hybridized to YACs that carried D11Nds1 and Mov9. The authors state that Mdsh maps to a 230kb fragment that contains Mov9 and D11Nds1. Mdsh also maps to a 550kb fragment that contains D11Nds1, Mov9 and D11Mit7. Collectively the gene order was suggested as - centromere - Trp53 - D11Mit7 - Mov9 - D11Nds1 - Mdsh - Evi2.