Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  13
• Reference
  J:81167 Tachibana M, et al., Hereditary keratoconus-like keratopathy in Japanese wild mice mapped to mouse Chromosome 13. Mamm Genome. 2002 Dec;13(12):692-5
• ID
  MGI:4462839

Genes

Gene
Krcn2
D13Mit252

Notes

• Experiment
  To map the QTL responsible for hereditary keratoconus a panel of backcross mice was generated by mating JKC (Japanese keratoconus) mice to BALB/cJ or C57BL/6J and backcrossing the F1s to JKC. The C57BL/6J backcross proved informative in that 41/331 mice exhibited a keratoconus-like phenotype. The 41 keratoconus positive mice coupled with 56 mice that did not exhibit the phenotype were utilized in mapping the phenotype to mouse Chromosome 13. The highest peak LOD score ( 5.13) was indicated in the region of D13Mit252 between cM 21.9 cM and 34 cM. Symbol Krcn2 represents this QTL region. Authors suggest Ctsj, Ctsr, Il9, Ctla2a, Eae13 and Lect2 as possible candidates for Krcn2.