Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  16
• Reference
  J:20522 Dietrich WF, et al., Genome-wide search for loss of heterozygosity in transgenic mouse tumors reveals candidate tumor suppressor genes on chromosomes 9 and 16. Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9451-5
• ID
  MGI:44037

Genes

Gene	Assay Type
D16Mit1	PCR amplified length variant
Loh2	PCR amplified length variant
D16Mit14	PCR amplified length variant

Notes

• Experiment
  Using SSLPs the authors assessed the LOH (loss of heterozygosity) in insulinomas and carcinoid tumors from F1 mice. The F1 hybrids were derived from CAST/Ei mice mated to C57BL/6J mice made congenic for SV40 Large T Ag (the transgene originated in the Rip1-Tag2 transgenic line). The F1 mice express metastatic tumors in the same way as the original Rip1-Tag2 transgenic line. LOH on Chromosomes 16 was significant and common to a 12.2 cM region bordered by D16Mit1 proximal and D16Mit14 distal. The authorsuse Loh2 to define this region and suggest that it and another on Chromosome 9 are important in the development of the tumor phenotype.