Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  4
• Reference
  J:19429 Herzog CR, et al., Deletion mapping of a putative tumor suppressor gene on chromosome 4 in mouse lung tumors. Cancer Res. 1994 Aug 1;54(15):4007-10
• ID
  MGI:43666

Genes

Gene	Assay Type
D4Mit18	PCR amplified length variant
D4Mit84	PCR amplified length variant
D4Mit81	PCR amplified length variant
D4Mit82	PCR amplified length variant
D4Mit27	PCR amplified length variant
D4Mit77	PCR amplified length variant
D4Mit15	PCR amplified length variant
D4Mit31	PCR amplified length variant

Notes

• Experiment
  The authors created a deletion map of a portion of mouse Chromosome 4 and measured the loss of heterozygosity (LOH) for lung tumors in order to map a putative tumor suppressor gene. An order was established of D4Mit18 - ~25.2 cM - D4Mit84 - ~1.1 cM - D4Mit81/D4Mit82 - ~3.0 cM - D4Mit27 - ~1.0 cM - D4mit77 - ~1.1 cM - D4Mit15 - ~11.4 cM - D4Mit31. In analyzing 42 lesions, all allelic loss was observed to involve the marker D4Mit77, in 2 cases, LOH was exclusive to this marker. Thus, the putative tumor suppressor gene was localized to an approximate 2 cM region flanking D4Mit77.