Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  4
• Reference
  J:17490 Neumann PE, et al., Multifactorial inheritance of neural tube defects: localization of the major gene and recognition of modifiers in ct mutant mice. Nat Genet. 1994 Apr;6(4):357-62
• ID
  MGI:43492

Genes

Gene	Allele	Assay Type
Tyrp1	Tyrp1^b	visible phenotype
D4Mit9		PCR amplified length variant
Pmv19		Southern analysis
D4Mit11		PCR amplified length variant
Pax7		Southern analysis
D4Nds2		PCR amplified length variant
Grhl3		visible phenotype
D4Mit13		PCR amplified length variant
D4Mit14		PCR amplified length variant
D4Smh6b		PCR amplified length variant
Dvl1		PCR amplified length variant

Notes

• Experiment
  In a series of crosses, an association of ct with the Pmv7 locus and the brown (b) locus on mouse Chromosome 4 was observed. Additional cross data were used to indicate the following gene order: D4Mit9 - 23 cM - D4Mit11 - D4Nds2 - 16 cM - D4Mit13 - 3 cM - D4Mit14 - 4 cM - D4Smh6b - Dvl. Pmv19 was placed 7 cMs proximal to D4Mit11 and Pax7 was placed 13 cMs distal to D4Mit11. The ct locus was mapped by its association with Neural tube defects (NTD) 3 cM proximal of D4Mit13. The ct gene on mouse Chromosome 4 has a major effect on neural tube defects. The severity and penetrance of NTD in mice is affected by modifier genes on Chromosomes 3 and 5.