Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  17
• Reference
  J:1094 Miyazawa M, et al., Detailed mapping of the Rfv-1 gene that influences spontaneous recovery from Friend retrovirus-induced leukaemia. Eur J Immunogenet. 1992 Jun;19(3):159-64
• ID
  MGI:41829

Genes

Gene	Assay Type
H2-D1	histocompatibility
Rfv1	resistance/susceptibility

Notes

• Experiment
  Rfv-1 was mapped to the D region of H-2 using congenic and recombinant mouse strains. (B6 x A.By)F1 is homozygous b/b at H-2D and is resistant to Friend leukemia virus 1. (B6.C-H-2^bm14 x A.By)F1, (B10.A x A.By)F1, (B10.A(18R) x A.By)F1, (B10.MBR x A.By)F1, (B10.BR x A.By)F1 and (B10.D2/n x A.By)F1 all have a heterozygous H-2D region and are susceptible to the virus. A transgenic strain, D8 (homozygous d/d in the D region), when made heterozygous for H-2D showed a minor inhibitory effect on recovery from FV leukemia. Since the presence of a non-D^b allele correlates with susceptibility and homozygous D^b mice are resistant, the authors conclude that Rfv-1 maps to the D region of H-2.