Mapping Data

Experiment

• Experiment
  HYBRID
• Chromosome
  16
• Reference
  J:8704 Lovett M, et al., The mouse homolog of the human amyloid beta protein (AD-AP) gene is located on the distal end of mouse chromosome 16: further extension of the homology between human chromosome 21 and mouse chromosome 16. Biochem Biophys Res Commun. 1987 Apr 29;144(2):1069-75
• ID
  MGI:38726

Genes

Gene
App

Notes

• Experiment
  Somatic cell hybrids were constructed using Chinese hamster line (360-6) and mouse spleen cells or mouse peritoneal macrophages. DNA was digested with PstI, Southern blotted and hybridized with human cDNA probe lambda Am4. Three of the hybrid lines were homozygous for one or both of the translocation products of T(2;16)28H and retained a portion of chromosome 16. The presence of the portion of chromosome 16 is designated as 16², distal as 2¹⁶. App can thus be assigned to distal chromosome 16.

HYBRID

• Band
  C3-qter
• Concordance
  chromosomes

HYBRID Data

Chromosome	+/+	+/-	-/+	-/-
2	1	4	4	1
3	1	1	4	4
4	2	2	3	3
5	0	1	5	4
6	0	0	5	5
7	3	1	2	4
8	2	1	3	4
9	1	0	4	5
10	1	2	4	3
11	0	0	5	5
12	1	2	4	3
13	1	1	4	4
14	0	2	5	3
15	1	3	4	2
16	2	0	0	4
17	0	0	5	5
18	3	3	2	2
19	2	3	3	2
X	3	2	2	3
2^16	3	0	0	1
16^2	1	1	0	0