Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  19
• Reference
  J:147432 Walrath JC, et al., Chr 19(A/J) modifies tumor resistance in a sex- and parent-of-origin-specific manner. Mamm Genome. 2009 Apr;20(4):214-23
• ID
  MGI:3842804

Genes

Gene
Nstr1

Notes

• Experiment
  Mouse Chromosome substitution strains (CSS) were informative in confirming the mapping of Nstr1 to mouse Chromosome 19. Nstr1 has a modifiying effect on peripheral nerve sheath tumors (PNSTs) which is evident in C57BL/6 J-NPcis mice. The Authors crossed C57BL/6J Chr 19^A/J/NaJ (B6-Chr19A) females to C57BL/6 J-NPcis B6-NPcis) males to generate B6-Chr19A X B6-NPcis (CSS19-NPcis^pat) progeny. The mating design is show figuratively in the text on page 216. The progeny showed a significant delay in tumor development confirming the contribution of a locus on chromosome 19.