Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  7
• Reference
  J:123468 Cascio M, et al., Mouse chromosome 7 harbors a quantitative trait locus for isoflurane minimum alveolar concentration. Anesth Analg. 2007 Aug;105(2):381-5
• ID
  MGI:3720163

Genes

Gene	Assay Type
Imacq	visible phenotype
D7Mit246	PCR

Notes

• Experiment
  Linkage analysis was performed on 90 animals from a C57BL/6J x (C57BL/6J x LP/J)F1 backcross to identify QTLs associated with isoflurane minimum alveolar concentration (MAC). A panel of 65 polymorphic markers was used for genome scan. Parental strain LP/J displays higher isoflurane MAC compared to parental strain C57BL/6J. The highest linkage was detected at 15 cM on mouse Chromosome 7 near D7Mi246 (LOD=1.7), corresponding to 30 Mb. C57BL/6J-derived alleles confer increased isoflurane MAC at this locus. SNP analysis of 19 inbred strains confirmed association of isoflurane MAC with the proximal chromosome 7 QTL. This locus is named Imacq (isoflurane minimum alveolar concentration QTL). Previously identified QTL mapping to chromosome 7 include Lorp1 (40 cM) and Etan1 (29 cM).