Mapping Data

Experiment

• Experiment
  TEXT-QTL-Candidate Genes
• Chromosome
  13
• Reference
  J:109356 Freeman HC, et al., Deletion of Nicotinamide Nucleotide Transhydrogenase: A New Quantitive Trait Locus Accounting for Glucose Intolerance in C57BL/6J Mice. Diabetes. 2006 Jul;55(7):2153-6
• ID
  MGI:3702937

Genes

Gene	Assay Type
Gluchos1	visible phenotype
Nnt	reported elsewhere

Notes

• Experiment
  Nnt maps to 64 cM on chromosome 13 and was previously identified as a strong candidate gene for Gluchos1. Gluchos1 mapped to 73 cM in an F2 intercross between C57BL/6J (impaired glucose homeostasis) and C3H/HeH (normal glucose homeostasis). C57BL/6J micehave a naturally occurring in-frame deletion of exons 7-11 in Nnt resulting in complete absence of gene product. Transgenic expression of a BAC vector containing a full-length Nnt gene derived from 129S6/SvEvTac in C57BL/6J animals resulted in Nnt protein production levels similar to C3H/HeH and rescue of glucose intolerance and insulin secretion.