Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  Y
• Reference
  J:16307 Roubertoux PL, et al., Co-segregation of intermale aggression with the pseudoautosomal region of the Y chromosome in mice. Genetics. 1994 Jan;136(1):225-30
• ID
  MGI:3696449

Genes

Gene	Assay Type
Imab	visible phenotype

Notes

• Experiment
  Congenic line analysis mapped a locus involved in intermale aggression to the pseudoautosomal region of the Y Chromosome. This locus is called Imab (intermale aggressive behavior). Male animals from inbred strain NZB/BlNJ display more intense and frequent aggression towards other male mice compared to inbred strain CBA/H.
  
  Male offspring from (CBA/H x NZB/BlNJ)F1 and (NZB/BlNJ x CBA/H)F1 mothers backcrossed to NZB/BlNJ fathers displayed significantly increased initiation of intermale aggressive behavior(69% -80%) compared to male offspring from F1 mothers backcrossed to CBA/H fathers (29%-38%) (P<0.0002). No maternal effect was observed. These results indicate that Imab is linked to the Y chromosome and is independent of mtDNA.
  
  Congenic animals carrying Y chromosome non-pseudoautosomal (NPAR) DNA derived from CBA/H on an NZB/BlNJ genetic background were constructed (N.H-Y^NPAR). The reciprocal congenic line H.N-Y^NPAR, which carries NZB/BlNJ-derived Y chromosome pseudoautosomal DNA on a CBA/H genetic background, was also constructed. Male congenic animals (at generations 29-30) did not differ in their attack intensity or frequency towards other male animals. Therefore Imab is excluded from the Y chromosome pseudoautosomal region.