Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  11
• Reference
  J:113755 Bernstein-Hanley I, et al., The p47 GTPases Igtp and Irgb10 map to the Chlamydia trachomatis susceptibility locus Ctrq-3 and mediate cellular resistance in mice. Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14092-7
• ID
  MGI:3694086

Genes

Gene	Assay Type
Ctrq3	resistance/susceptibility
D11Mit164	PCR amplified length variant
Igtp	reported elsewhere

Notes

• Experiment
  Ctrq3 (C. trachomatis resistance 3) was previously mapped to 32 cM on mouse Chromosome 11 in a (C57BL/6J x C3H/HeJ)F2 intercross. Parental strain C57BL/6J is resistant to C. trachomatis infection compared to parental strain C3H/HeJ. Congenic line analysis refined the Ctrq3 interval to a 1.2 Mb region between D11Mit164 and D11Zbh12. This region contains 18 genes, two of which are proposed as candidates for Ctrq3. Igtp (32 cM) and Irgb10 both exhibit amino acid polymorphisms between C57BL/6J and C3H/HeJ. In vitro analysis of Irgb10 expression showed 20-fold increased expression in IFN-gamma treated mouse embryonic fibroblasts (MEFs) derived from C57BL/6J compared to C3H/HeJ. In addition, MEFs derived from heterozygous Ctrq3 congenics showed 2-fold decreased Irgb10 expression compared to background strain C57BL/6J.