Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  2
• Reference
  J:114155 Rangnekar AS, et al., Quantitative trait loci analysis of mice administered the methionine-choline deficient dietary model of experimental steatohepatitis. Liver Int. 2006 Oct;26(8):1000-5
• ID
  MGI:3690344

Genes

Gene	Assay Type
Nashs1	visible phenotype
Hc	reported elsewhere
Traf2	reported elsewhere

Notes

• Experiment
  QTL analysis was performed on female animals from 7 inbred strains to identify genetic loci associated with nonalcoholic steatohepatitis (NASH) phenotypes. Animals were fed a methionine-choline-deficient (MCD) diet to induce NASH and measured for serum alanine aminotransferase (ALT), hepatic triglycerides, liver weight, and weight loss. Inbred strain A/J exhibits the greatest serum ALT and weight loss compared to other inbred strains. Inbred strain DBA/2J exhibited the least weight loss of all 7 strains.In silico QTL mapping was performed using polymorphic markers from an SNP database.
  
  Serum ALT and liver weight mapped to 0 cM - 30 cM on mouse Chromosome 2 and 0 cM - 30 cM on mouse Chromosome 15. These QTLs are named Nashs1 (nonalcoholic steatohepatitis susceptibility 1) and Nashs2 (nonalcoholic steatohepatitis susceptibility 2), respectively. Potential candidate genes for Nashs1 include Hc (23.5 cM), interleukin 1 family genes (10 cM), and Traf2.
  
  Linkage to liver weight mapped to mouse Chromosomes 5and 11. Linkage to serum ALT mapped to mouse Chromosomes 1 and 7. Suggestive linkage to weight loss mapped to mouse Chromosomes 11 and 14.