Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  16
• Reference
  J:110101 Paylor R, et al., Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7729-34
• ID
  MGI:3653733

Genes

Gene
Del(16Cldn5-Hira)5Bld
Del(16Es2el-Sept5)3Bld
Del(16Es2el-T10)2Bld
Del(16Es2el-Ufd1l)217Bld
Del(16T10-Hira)4Bld
Ess2
Hira
Tbx1
Gnb1l

Notes

• Experiment
  The following deletions were mapped to a region of mouse Chromosome 16 that included Es2el, Hira, Gnb1l and Tbx1: Del(16Cldn5-Hira)5Bld , Del(16Es2el-Sept5)3Bld , Del(16Es2el-T10)2Bld , Del(16Es2el-Ufd1l)217Bld and Del(16T10-Hira)4Bld.
  
  The authors indicate that a mutation of Gnb1l or Tbx1 is sufficient to cause reduced PPI (prepulse inhibition).
  
  The deleted region is conserved with 22q11 in humans.