Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  3
• Reference
  J:109795 Kenney-Hunt JP, et al., Quantitative trait loci for body size components in mice. Mamm Genome. 2006 Jun;17(6):526-37
• ID
  MGI:3639922

Genes

Gene	Assay Type
Lbn3	visible phenotype
D3Mit22	PCR
Ptx3	reported elsewhere
Mlf1	reported elsewhere
Shox2	reported elsewhere
Org2	visible phenotype
D3Mit12	PCR

Notes

• Experiment
  Genetic loci associated with long bone length, necropsy body weight, and organ weight were mapped in 1045 animals from a (LG/J x SM/J)F2 intercross. Animals were phenotyped between 70 and 237 days of age, with an average age at sacrifice of 144 days. Twodifferent sets of F2 mice were genotyped for 75 and 96 polymorphic markers across 19 autosomes. 97 single trait QTL were identified. After pleiotropy analysis the 97 loci coalesced into 35 pleiotropic QTLs. Cutoff for statistical significance is LPR=3.49but all pleiotropic loci listed in the reference are reported here.
  
  On mouse Chromosome 3, linkage to long bone measurements, Lbn3 (long bones 3), mapped to 33.7 cM near D3Mit22 (LPR=6.67). The confidence interval spans 42 cM - 56 cM. Potential candidate genes mapping near Lbn3 include Ptx3 (33.8 cM), Mlf1 (31 cM), and Shox2 (31.6 cM).
  
  Linkage to spleen weight, Org2 (organ weight 2), was detected at 49 cM near D3Mit12 (LPR=3.49). The Org2 confidence interval spans 40 cM - 78 cM.