Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  7
• Reference
  J:108419 Kobayashi M, et al., Serum adiponectin concentration: its correlation with diabetes-related traits and quantitative trait loci analysis in mouse SMXA recombinant inbred strains. Biosci Biotechnol Biochem. 2006 Mar;70(3):677-83
• ID
  MGI:3624651

Genes

Gene	Assay Type
D7Mit250	PCR amplified length variant
D7Mit297	PCR amplified length variant
D7Nds1	PCR amplified length variant
Nr2f2	reported elsewhere
D7Mit7	PCR amplified length variant
D7Mit10	PCR amplified length variant

Notes

• Experiment
  Suggestive linkage to serum adiponectin mapped to 2 loci on mouse Chromosome 7 in 10 SMXA (SM=SM/J; A=A/J) recombinant inbred (RI) strains. A panel of 789 polymorphic marker were used for the genome scan. Parental strain SM/J exhibits significantly higher serum adiponectin concentrations and significantly lower body mass index (BMI), liver weight, and serum cholesterol compared to parental strain A/J.
  
  Suggestive linkage to serum adiponectin concentration mapped to 37 cM on mouse Chromosome 7 near D7Mit250 (LOD=2.8). This interval spans 27.8 cM to 37 cM (52.8 Mb - 61.7 Mb) between D7Mit297 and D7Nds1). The A/J-derived allele at this locus confers increased serum adiponectin concentration. Nr2f2 (formerly Arp1) at 33 cM is a potential candidate gene for this locus.
  
  A second locus for serum adiponectin mapped 54 cM on mouse Chromosome 7 near D7Mit7 (LOD=2.3). This interval spans 54 cM to 66 cM (unknown - 124 Mb) between D7Mit7 and D7Mit10. The A/J-derived allele at this locus confers increased serum adiponectin concentration.