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Mapping Data
  • Experiment
  • Chromosome
  • Reference
    J:103841 Stylianou IM, et al., Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm Genome. 2006 Jan;17(1):22-36
  • ID
GeneAlleleAssay TypeDescription
Obwq5 visible phenotype
D19Mit71 PCR amplified length variant
  • Experiment
    Linkage analysis was performed on 513 animals from a (SM/J x NZB/BlNJ)F2 intercross to identify QTL affecting obesity traits. Animals were placed on an atherogenic diet for 16 weeks before phenotyping. Parental strain SM/J exhibits smaller body size but higher adiposity compared to parental strain NZB/BlNJ.

    Obwq5 maps to 52 cM on mouse Chromosome 19 near D19Mit71 (LOD=9.3) with a 95% confidence interval spanning approximately 36 cM - 54 cM. NZB/BlNJ-derived alleles confer increased body weight and all fat pad weights with a recessive mode of inheritance. Obwq5 appears to be at the center of a network of interacting loci. Ins2 (69.1 cM) on mouse Chromosome 7 and Fgf8 (45 cM) on mouse Chromosome 19 are 2 prominent genes in this network. Adip15 (52 cM) onchromosome 10 and Obwq2 (44 cM) on chromosome 5 are also involved in the Obwq5 network.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
The Jackson Laboratory