Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  19
• Reference
  J:103841 Stylianou IM, et al., Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm Genome. 2006 Jan;17(1):22-36
• ID
  MGI:3615289

Genes

Gene	Assay Type
Obwq5	visible phenotype
D19Mit71	PCR amplified length variant

Notes

• Experiment
  Linkage analysis was performed on 513 animals from a (SM/J x NZB/BlNJ)F2 intercross to identify QTL affecting obesity traits. Animals were placed on an atherogenic diet for 16 weeks before phenotyping. Parental strain SM/J exhibits smaller body size but higher adiposity compared to parental strain NZB/BlNJ.
  
  Obwq5 maps to 52 cM on mouse Chromosome 19 near D19Mit71 (LOD=9.3) with a 95% confidence interval spanning approximately 36 cM - 54 cM. NZB/BlNJ-derived alleles confer increased body weight and all fat pad weights with a recessive mode of inheritance. Obwq5 appears to be at the center of a network of interacting loci. Ins2 (69.1 cM) on mouse Chromosome 7 and Fgf8 (45 cM) on mouse Chromosome 19 are 2 prominent genes in this network. Adip15 (52 cM) onchromosome 10 and Obwq2 (44 cM) on chromosome 5 are also involved in the Obwq5 network.