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Mapping Data
Experiment
  • Experiment
    TEXT-QTL
  • Chromosome
    2
  • Reference
    J:103841 Stylianou IM, et al., Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm Genome. 2006 Jan;17(1):22-36
  • ID
    MGI:3615277
Genes
GeneAlleleAssay TypeDescription
Adip10 visible phenotype
D2Mit1 PCR amplified length variant
Bwtq8 visible phenotype
D2Mit92 PCR amplified length variant
Notes
  • Experiment
    Linkage analysis was performed on 513 animals from a (SM/J x NZB/BlNJ)F2 intercross to identify QTL affecting obesity traits. Animals were placed on an atherogenic diet for 16 weeks before phenotyping. Parental strain SM/J exhibits smaller body size but higher adiposity compared to parental strain NZB/BlNJ.

    On mouse Chromosome 2, Adip10 maps to 2 cM near D2Mit1 (LOD=3.5) with a 95% confidence interval spanning approximately 0 cM - 34 cM. SM/J-derived alleles at Adip10 confer increased inguinal and retroperitoneal fat pad weights with an additive mode of inheritance. Previously identified obesity QTL Obq3 (53 cM), Mob6 (49.6 cM), and Fob1 (45 cM) maps near the Adip10 interval.

    Bwtq8 maps to 42 cM near D2Mit92 (LOD=4) with a 95% confidence interval spanning approximately 34 cM - 78 cM. NZB/BlNJ-derived alleles at Bwtq8 confer increased lean body weight with and additive mode of inheritance. Bwq5 (81.7 cM), Nidd5 (34.5 cM), and Pbwg1 (32.8 cM) are previously identified body weight QTL located near Bwtq8.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory