Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:6736 Davidson WF, et al., Chromosome 1 locus required for induction of CTL to H-2-compatible cells in NZB mice. Immunogenetics. 1982 Mar;15(3):321-5
• ID
  MGI:3612084

Genes

Gene	Assay Type
Ctl1	visible phenotype
Ly9	reported elsewhere

Notes

• Experiment
  Linkage analysis was performed on a population of (NZB/BlN x B10.D2/oSnJ)F1 x B10.D2/oSnJ backcross animals to map loci affecting cytotoxic T lymphocyte (CTL) response to H2-compatible cells. Parental strain NZB/BlN exhibits increased in vitro CTL response to H2-compatible cells. Ctl1 (cytotoxic T lymphocyte response 1) showed linkage to mouse Chromosome 1 near Ly9 (93.9 cM). Animals heterozygous for NZB/BlN-derived alleles at Ctl1 exhibit stronger CTL response compared to animals homozygous for B10.D2/oSnJ-derived alleles.