Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  17
• Reference
  J:6974 Bonner JJ, et al., Backcross test demonstrates the linkage of glucocorticoid-induced cleft palate susceptibility to H-2. Teratology. 1982 Oct;26(2):213-6
• ID
  MGI:3608994

Genes

Gene	Assay Type
Dxcp1	visible phenotype
Dxcp2	visible phenotype
H2	reported elsewhere

Notes

• Experiment
  Susceptibility to dexamethasone-induced cleft palate mapped to the H2 locus on mouse Chromosome 17 in a population of (B10.A/SgSnJ x C57BL/10/SnJ)F1 x C57BL/10/SnJ backcross animals. These loci are named Dxcp1 (19.5 cM) and Dxcp2 (18.975 cM). The A/WySnJ-derived allele (H2^a) from B10.A/SgSnJ is associated with susceptibility to dexamethasone-induced cleft palate whereas the C57BL/10SnJ-derived allele (H2^b) is associated with resistance. Heterozygous backcross animals exhibit a 28.9% incidence of dexamethasone-induced cleft palate compared to 11.9% in animals homozygous for C57BL/10SnJ-derived alleles at the H2 locus.