Mapping Data

Experiment

• Experiment
  TEXT-QTL-Candidate Genes
• Chromosome
  6
• Reference
  J:99471 Rosen CJ, et al., Allelic differences in a quantitative trait locus affecting insulin-like growth factor-I impact skeletal acquisition and body composition. Pediatr Nephrol. 2005 Mar;20(3):255-60
• ID
  MGI:3607509

Genes

Gene	Assay Type
Igf1sl1	visible phenotype
Alox5	reported elsewhere

Notes

• Experiment
  Igf1sl1 is a QTL previously identified in a congenic line named B6.C3-(D6Mit93-D6Mit150). Authors refer to this line as 6T. The congenic carries a C3H/HeJ-derived interval between D6Mit93 (26.3 cM) to D6Mit150 (51 cM) on a C57BL/6J genetic background. The congenic exhibits 30%-50% decreased IGF-1 expression in bone, liver, and fat tissue, and a 20% decrease in serum IGF-1 levels compared to background strain C57BL/6J. IGFBP-2 expression also appears to be decreased in bone. The congenic also exhibits decreased rate of bone formation and significantly increased percent body fat compared to C57BL/6J.
  
  B6.C3-(D6Mit93-D6Mit150) did not respond well to parathyroid hormone (PTH) treatment as bone mineral density did not increased significantly after 4 week of daily injections with PTH.
  
  Alox5 (53.2 cM) is a potential candidate gene mapping near Igf1sl1.