Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  6
• Reference
  J:98477 Gill KJ, et al., Quantitative trait loci for novelty/stress-induced locomotor activation in recombinant inbred (RI) and recombinant congenic (RC) strains of mice. Behav Brain Res. 2005 Jun 3;161(1):113-24
• ID
  MGI:3580554

Genes

Gene	Assay Type
Nsila5	visible phenotype
D6Mit264	PCR

Notes

• Experiment
  QTLs associated with novelty/stress-induced locomotor activation were mapped using a series of recombinant inbred (RI) and recombinant congenic (RC) strains derived from C57BL/6J and A/J progenitor strains. Progenitor strain C57BL/6J exhibits greater activation of locomotor activity when placed in a novel open field environment compared to progenitor strain A/J. 1159 animals from the AXB/BXA RI series were genotyped with a panel of 780 polymorphic markers. 13 AcB and 31 BcA RC strains were genotyped witha panel of 625 polymorphic markers.
  
  In the AcB/BcA RC population, a locus at 3.2 cM on mouse Chromosome 6 near D6Mit264 showed significant linkage to locomotor activation in a novel environment. This locus is designated Nsila5 (novelty/stress induced locomotor activation 5). The Nsila5 QTL interval spans 0.5 cM - 20.4 cM. The C57BL/6J-derived allele at Nsila5 is associated with increased novelty/stress induced activation of locomotor activity.