Mapping Data

Experiment

• Experiment
  TEXT-QTL-Candidate Genes
• Chromosome
  2
• Reference
  J:98587 Hitzemann R, et al., On the integration of alcohol-related quantitative trait loci and gene expression analyses. Alcohol Clin Exp Res. 2004 Oct;28(10):1437-48
• ID
  MGI:3580133

Genes

Gene
Actre2
Scg5
Cd59a

Notes

• Experiment
  Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to 6 previously identified alcohol-related QTLs to identify potential candidate genes. Two different Affymetrix microarrays were used in the analysis. Brain expression data from parental strains and 56 (DBA/2J x C57BL/6J)F2 intercross animals were used for analysis.
  
  On mouse Chromosome 2, the highest priority candidate genes identified for Actre2 at 48 cM are Cd59a (55 cM) and Scg5 (64 cM). Other candidate genes with a ranking of modest priority were identified but are not listed here.