Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  6
• Reference
  J:75407 Barth RK, et al., Mapping susceptibility genes for the induction of pulmonary fibrosis in mice. Chest. 2002 Mar;121(3 Suppl):21S
• ID
  MGI:3575932

Genes

Gene
Pfibs1

Notes

• Experiment
  Inbred mouse strain (DBA/2) is highly susceptible to bleomycin-induced pulmonary fibrosis and is genetically very dissimilar to the standard fibrosis-sensitive strain, C57BL/6. The strain difference enabled the authors to genetically map the loci underlying the phenotype. One marker named Pfibs1, mapped within a region of mouse Chromosome 6 that contains a cluster of genes that are members of the tumor necrosis factor (TNF)-receptor family. A second locus, Pfibs2 mapped within a region of mouse Chromosome 13 that included the Fgf gene family.