Mapping Data

Experiment

• Experiment
  TEXT-QTL-Candidate Genes
• Chromosome
  6
• Reference
  J:90940 Manenti G, et al., Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice. Oncogene. 2004 May 27;23(25):4495-504
• ID
  MGI:3575827

Genes

Gene	Assay Type
Pas15	resistance/susceptibility
D6Int24
D6Int15
Bcat1	reported elsewhere
Irag2	reported elsewhere
Kras	reported elsewhere
Lmntd1	reported elsewhere
Etfrf1	reported elsewhere
Dnai7	reported elsewhere

Notes

• Experiment
  The Pas15 lung tumor susceptibility locus was localized to a 486 kb region on mouse Chromosome 6 by fine mapping of the recombinant congenic (RC) strain CXB5/ByJ. CXB5/ByJ is derived from BALB/cJ and C57BL/6J progenitor strains and is highly resistant to lung tumor development. Genotyping of 65 markers in 29 inbred strains for a 1 Mb region around Pas15 revealed a core haplotype that is either C57BL/6-derived or A/J-derived. The Pas1 critical region contains 6 candidate genes: Bcat1, Lrmp, Kras, Casc1, 4933403M22Rik, and 4930469P12Rik. In lung tumors from (A/J x C57BL/6J)F1 mice, Casc1 appears to be expressed solely from the A/J allele and expression of 4933403M22Rik appears to be completely downregulated.